Lead Bioinformatics Scientist, NGS Job at Profluent, Emeryville, CA

aFRaMWY4QWxQaVowNStRVFY3dFczUkprdXc9PQ==
  • Profluent
  • Emeryville, CA

Job Description

Profluent is an AI-first protein design company. Founded in 2022, we develop deep generative models to design and validate novel, functional proteins to revolutionize biomedicine. Based in Emeryville, CA, we are backed by leading investors including Spark Capital, Insight Partners, Air Street Capital, AIX Ventures, and Convergent Ventures.

The Role

We're seeking an experienced computational scientist to lead the design, development, and operation of the NGS analysis platform that powers Profluent's gene editing and protein design programs. You'll work at the intersection of computational biology, software engineering, and experimental biology to build scalable systems that extract clear, actionable insights from large-scale sequencing data.

In this role, you'll architect core bioinformatics infrastructure, define analytical strategy, and collaborate closely with experimental and ML teams to accelerate design-build-test-learn cycles. You'll also mentor team members, promote software engineering best practices, and help shape the future of Profluent's computational biology capabilities.
Responsibilities
  • Lead design and implementation of scalable NGS analysis pipelines supporting gene editing and protein engineering workflows
  • Develop clear, intuitive visualizations and reports to communicate sequencing results and biological insights
  • Manage cloud-based compute environments and data systems for large-scale datasets
  • Partner with biology teams to analyze results, troubleshoot, and optimize experimental design
  • Collaborate with machine learning teams to curate data for model training
  • Establish best practices for code review, testing, and CI/CD in computational workflows
  • Mentor junior scientists and foster a culture of rigor, reproducibility, and innovation

Qualifications

  • PhD or MS in Bioinformatics, Computational Biology, Computer Science, or a related quantitative field
  • 5+ years of experience analyzing NGS datasets (e.g., amplicon sequencing, high-throughput editing, or screening experiments)
  • Strong programming skills in Python (pandas, numpy, biopython, etc.)
  • Expertise with workflow orchestration tools (Nextflow, Snakemake) and cloud environments (GCP, AWS)
  • Experience with containerization (Docker, Kubernetes) and scalable compute infrastructure
  • Deep understanding of Linux, git-based version control, and software engineering best practices
  • Proven ability to transform complex sequencing data into actionable biological insights

Preferences

  • Experience with gene editing technologies (CRISPR, base or prime editing; strongly preferred)
  • Familiarity with SQL and data modeling for biological or experimental data
  • Experience with LIMS platforms (e.g., Benchling) and lab data integration
  • Track record of developing production-quality scientific software or open-source bioinformatics tools

What We Offer

  • High-growth opportunity with meaningful impact on the future of protein design
  • Competitive compensation package with equity participation
  • Comprehensive benefits including health/dental/vision insurance
  • Generous PTO policy and commitment to work-life balance
  • Professional development opportunities in a cutting-edge field at the intersection of AI and biology

Work Authorization

Candidates must have ongoing work authorization in the United States that does not require employer sponsorship. Sponsorship will not be provided for this position.

Profluent Bio, Inc. is an equal opportunity employer committed to diversity and inclusion in the workplace.

Hiring Salary Range

$160,000-$230,000 USD

Job Tags

Full time,

Similar Jobs

Hyundai America Technical Center, Inc. (HATCI)

CMF Design Senior Designer Job at Hyundai America Technical Center, Inc. (HATCI)

Job description: CMF Design Senior Designer WHAT YOU WILL DO Main role : As CQM (Color Quality Management) Designer, you will...  ...be working on projects such as production programs, concept cars, assisting re-work of press vehicles, autoshow cars, re-work of... 

Unified Women's Healthcare

HRIS Analyst and LMS Administrator Job at Unified Women's Healthcare

HRIS Analyst and LMS Administrator Location Remote in Florida : Overview: Unified Women's Healthcare is a company dedicated to caring for Ob-Gyn providers who care for others, be they physicians or their support staff. A team of like-minded professionals with significant... 

Dunkin'

Restaurant Assistant Manager Job at Dunkin'

 ...At Dunkin', we are not just an employer--we're a family. We invest our all into our Restaurant Assistant Managers to ensure that they are able to learn and grow in their careers, as well as individuals. If you are looking for a career that is fun and fulfilling with a... 

Westinghouse Electric - USA

IT Recruiter Job at Westinghouse Electric - USA

 ...Job Title: IT Recruiter Location: Onsite Juno Beach, FL Schedule: 40 hours per week Contract Duration: 45 months Pay Range: $41$46/hour Job Overview: We are seeking a skilled and proactive IT Recruiter for a 45 month contract position onsite... 

Cigna

Part-Time After Hours Staff Pharmacist - Remote, IL Job at Cigna

 ...PartTime Remote Staff Pharmacist Location: Remote, anywhere within the US Schedule:...  ...Technical & Professional Skills Work across VPNs, automation systems, and multiple...  ...weekends If you will be working at home occasionally or permanently, the internet...